How to Pronounce Tezspire

Meaning and Context

Tezspire, with the generic name tezepelumab-ekko, is a groundbreaking biologic medication approved by the U.S. Food and Drug Administration (FDA) in December 2021 for the add-on maintenance treatment of severe asthma. Unlike earlier biologics that target specific inflammatory pathways like IgE or IL-5, Tezspire works upstream by binding to and inhibiting thymic stromal lymphopoietin (TSLP), a key epithelial cytokine that initiates multiple downstream inflammatory processes. This novel mechanism of action makes it the first and only biologic indicated for severe asthma regardless of phenotype, meaning it can be effective for patients with or without high eosinophil counts and irrespective of allergic status. Its clinical significance lies in its ability to significantly reduce the annualized asthma exacerbation rate and improve lung function, as demonstrated in the pivotal NAVIGATOR phase 3 trial, offering new hope for patients with uncontrolled severe asthma who have limited treatment options. The medication is administered via subcutaneous injection every four weeks and represents a major advancement in personalized asthma management and targeted biologic therapy.

Common Mistakes and Alternative Spellings

The primary spelling, "Tezspire," is a brand name and must be capitalized. A common and critical error is misspelling it as "Tezspire" with an extra 'e' (e.g., "Tezespire"), or transposing letters to form "Tezspire." The generic name, tezepelumab-ekko, also presents frequent spelling challenges. It is often misspelled by omitting the hyphen ("tezepelumab ekko") or the suffix ("tezepelumab"), though the suffix "-ekko" is part of the official nonproprietary name. Other common typos include "tezpulumab," "tezeplumab," or confusing the 'z' with an 's' as in "tesepelumab." In written communication, it is important to distinguish between the brand name (Tezspire) and the generic name (tezepelumab-ekko), and to avoid informal abbreviations like "Tez" in professional or medical contexts, as this can lead to confusion with other medications or unclear documentation.

Example Sentences

After struggling with uncontrolled eosinophilic asthma for years, Maria's pulmonologist recommended starting Tezspire to target the underlying inflammation.

The clinical trial data showed that tezepelumab-ekko significantly reduced exacerbations in patients with severe asthma, even those with low biomarker levels.

Patients administering Tezspire at home must be trained on proper subcutaneous injection techniques.

"Since adding Tezspire to my maintenance regimen, I've had fewer emergency room visits and my quality of life has improved dramatically," the patient reported.

The hospital's pharmacy and therapeutics committee reviewed the cost-effectiveness of Tezspire before adding it to the formulary for severe asthma management.

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